No. Resources are read only, because they are embedded into the EXE file and do not exist as "normal files". Even if you could do it, your anti-virus software would be all over you, and they track file changes and alert when an exe gets modified.
There is also the problem that in production the Program Files folder and it's subdirectories is read only, to reduce virus activity and your app would require elevation to write to the file, even if instead of embedding them you add them as files that are installed in the app folder by the installer.
Instead, have your code check if the file exists in a safe place on start up, and if it doesn't then copy the resource to it. Then use that file, and write your revised data into the "safe location" copy. If you have a look here it explains where to store such data:
Where Should I Store My Data?[
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