CodeProject has several articles that will teach you how to use User Settings. In my opinion using User Settings is a good strategy for cases like yours where a small number of settings need to be saved, and then used when the Application opens to configure the Application.
This article is a good practical introduction that will get you started right away: [
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This article gives you a good overview and understanding of User Settings across various .NET platforms including Win Forms, WPF, etc. : [
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This article provides a reusable component that you can use for persisting application settings; imho, it may be useful when you have many settings to save/restore: [
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