If you are designing in a WinForms component, which is anything that derives from Control at some point (Forms, UserControls, panels, etc), then you can use the following code:
<br />
if (this.Site.DesignMode)<br />
[edit]
The above will throw an exception if Site is not set (in most cases it is, ie the control is in a container control). However:
if (this.DesignMode)
Will return false if there is no container. This is an alternative (and much neater) method, but may give incorrect results in certain (rare) circumstances.