Yes.
Try the code
private void RemoveClickEvent(Button b)
{
FieldInfo f1 = typeof(Control).GetField("EventClick",
BindingFlags.Static | BindingFlags.NonPublic);
object obj = f1.GetValue(b);
PropertyInfo pi = b.GetType().GetProperty("Events",
BindingFlags.NonPublic | BindingFlags.Instance);
EventHandlerList list = (EventHandlerList)pi.GetValue(b, null);
list.RemoveHandler(obj, list[obj]);
}