C#

[DllImport("user32.dll", SetLastError=true)]
public static extern bool RegisterHotKey(
    IntPtr hWnd,         // handle to window
    int id,            // hot key identifier
    KeyModifiers fsModifiers,  // key-modifier options
    Keys vk            // virtual-key code
    );
 
[DllImport("user32.dll", SetLastError=true)]
public static extern bool UnregisterHotKey(
    IntPtr hWnd,  // handle to window
    int id      // hot key identifier
    );
 
[Flags()]
public enum KeyModifiers
{
    Alt = 1,
    Control = 2,
    Shift = 4,
    Windows = 8
}

bool success = RegisterHotKey(Handle, 100, 
    KeyModifiers.Control | KeyModifiers.Shift, Keys.J);
System.Diagnostics.Trace.WriteLine(
    "Success = " + success.ToString());

UnregisterHotKey(Handle, 100);

protected override void WndProc( ref Message m )
{
	const int WM_HOTKEY = 0x0312;
 
	switch(m.Msg)
	{
	case WM_HOTKEY:
		MessageBox.Show("Hotkey pressed");
		break;
	}
 
	base.WndProc(ref m );
}