Try this
<asp:panel defaultbutton=""button1"" runat=""server"><br" mode="hold" xmlns:asp="#unknown" /> <asp:textbox id="textbox1" runat="server"/>
<asp:textbox id="textbox2" runat="server"/>
<asp:button id="button1" text="Button1" runat="server"/> <asp:panel xmlns:asp="#unknown">
<asp:panel defaultbutton="button2" runat="server">
<asp:textbox id="textbox3" runat="server"/>
<asp:button id="button2" runat="server"/>
</asp:panel>