Mr Vishal try like this,
string str = ",";
string mtr = "/";
foreach (DataRow datarow in dataset.Tables[0].Rows)
{
foreach(DataColumn datacol in dataset.Tables[0].Columns)
{
datarow[datacol]= regex.Replace(datarow[datacol].ToString(), str.tostring, mtr.tostring);
}
}
Mark as Answer if it helps.