If you check your errors cause detail, you will find problem solution.
check here
Exception Details: System.UnauthorizedAccessException: Access to the path '~\Upload\NewsImage' is denied..
ASP.NET is not authorized to access the requested resource. Consider granting access rights to the resource to the ASP.NET request identity. ASP.NET has a base process identity (typically {MACHINE}\ASPNET on IIS 5 or Network Service on IIS 6 and IIS 7, and the configured application pool identity on IIS 7.5) that is used if the application is not impersonating. If the application is impersonating via <identity impersonate="true"/>, the identity will be the anonymous user (typically IUSR_MACHINENAME) or the authenticated request user.
To grant ASP.NET access to a file, right-click the file in Explorer, choose "Properties" and select the Security tab. Click "Add" to add the appropriate user or group. Highlight the ASP.NET account, and check the boxes for the desired access.
if you can reach your server, open your file which was located under the inetpub >> vhosts >> domainnames.com >> httpdocs >> find in your project files Uploads file and
do this
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To grant ASP.NET access to a file, right-click the file in Explorer, choose "Properties" and select the Security tab. Click "Add" to add the appropriate user or group. Highlight the ASP.NET account, and check the boxes for the desired access
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if you arent owner of server and can not reach to server with remote connection then
use your panel for manage domains and files then give write and modify permissions to your files and child files