An extra long list of drop down is definitely a nightmare, multi-column or even multi-dropdown is not going to make it any better. If the list items can be grouped onto a few categories, then first have radio buttons for choosing the category, then filter and populate the dropdown based on the selected category. Another way, consider an auto-complete drop down. There are many examples if you ask Google. Here is one such discussion:
http://baymard.com/blog/drop-down-usability[
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